Boston University

Optical Characterization and Nanophotonics Laboratory

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[Books & Chapters][Journal Articles][Conference Papers][Theses]

Philipp Stefan Spuhler

Research Associate
Doctor of Philosophy
Boston University
Boston, MA 02215

Projects

Interferometric Reflectance Imaging Sensor

Opto-Electrical Wireless Neural Stimulators

Platform for Quantified High-throughput Measurement of Protein Induced Conformation Changes in DNA

Self-Interference Fluorescence Microscopy

Books & Chapters

1.) X. Zhang, P. S. Spuhler, D. S. Freedman, and M. S. Ünlü, "Spectral Self-Interference Fluorescence Microscopy to Study Conformation of Biomolecules with Nanometer Accuracy," Nanoscale Spectroscopy with Applications, November 2013

Journal Articles

7.) X. Zhang, G. G. Daaboul, P. S. Spuhler, P. Dröge, and M. S. Ünlü, "Quantitative characterization of conformational-specific protein–DNA binding using a dual-spectral interferometric imaging biosensor," Nanoscale, No. DOI: 10.1039/C5NR067, 2016

6.) X. Zhang, G. G. Daaboul, P. S. Spuhler, D. S. Freedman, A. Yurt, S. Ahn, O. Avci, and M. S. Ünlü, "Nanoscale Characterization of DNA Conformation Using Dual-color Fluorescence Axial Localization and Label-free Biosensing," Analyst, 13 October 2014

5.) P. S. Spuhler, L. Sola, X. Zhang, M. R. Monroe, J. T. Greenspun, M. Chiari, and M. S. Ünlü, "Precisely Controlled Smart Polymer Scaffold for Nanoscale Manipulation of Biomolecules," Analytical Chemistry, Vol. 84, November 2012, pp. 10593–10599

4.) S. Ahn, P. S. Spuhler, M. Chiari, M. Cabodi, and M. S. Ünlü, "Quantification of surface etching by common buffers and implications on the accuracy of label-free biological assays ," Biosensors and Bioelectronics, Vol. 36, June 2012, pp. 222-229

3.) G. di Carlo, F. Damin, M. S. Ünlü, P. S. Spuhler, and M. Chiari, "Synthesis and conformational characterization of functional di-block copolymer brushes for microarray technology," Surface Science, Vol. 258, 1 February 2012, pp. 3750-3756

2.) A. Abdo, M. Sahin, D. S. Freedman, E. Cevik, P. S. Spuhler, and M. S. Ünlü, "Floating light-activated microelectrical stimulators tested in the rat spinal cord," Journal of Neural Engineering, Vol. 8, No. 5, October 2011

1.) P. S. Spuhler, J. Knezevic, A. Yalcin, Q. Bao, E. Pringsheim, P. Dröge, U. Rant, and M. S. Ünlü, "Platform for in situ real-time measurement of protein-induced conformational changes of DNA ," Proceedings of the National Academy of Science, 4 January 2010

Conference Papers

13.) X. Zhang, G. G. Daaboul, P. S. Spuhler, D. S. Freedman, A. Yurt, S. Ahn, and M. S. Ünlü, "Quantification of DNA hybridization by nanoscale axial localization and label-free biosensing," BMES 2013 Annual Meeting , 22-25 October 2013

12.) X. Zhang, P. S. Spuhler, L. Sola, M. Chiari, and M. S. Ünlü, "A high speed micro-arrayed biosensing platform for the detection of specific DNA-protein interactions," Biosensors, 2012, Cancun, Mexico, 15-18 May 2012

11.) P. S. Spuhler, L. Sola, X. Zhang, M. R. Monroe, J. T. Greenspun, M. Chiari, and M. S. Ünlü, "A Nano-Electromechanical Biosensor Based on Precise Quantification and Control of DNA Orientation," 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 3 September 2011

10.) P. S. Spuhler, L. Sola, X. Zhang, M. R. Monroe, J. T. Greenspun, M. Chiari, and M. S. Ünlü, "Precise Control of DNA Orientation for Improved Functionality in Protein Binding Microarrays," International Conference on Optical MEMS & Nanophotonics, August 2011

9.) A. Abdo, M. Sahin, D. S. Freedman, E. Cevik, P. S. Spuhler, and M. S. Ünlü, "Intraspinal Stimulation with Light Activated Micro-Stimulators," 5th International IEEE EMBS Conference on Neural Engineering, 29 April 2011

8.) D. S. Freedman, P. S. Spuhler, E. Cevik, M. S. Ünlü, and M. Sahin, "Addressable Floating Light Activated Micro-Electrical Stimulators for Wireless Neurostimulation," 5th International IEEE EMBS Conference on Neural Engineering, 29 April 2011

7.) M. S. Ünlü, P. S. Spuhler, L. Sola, M. R. Monroe, X. Zhang, and M. Chiari, "A platform for the precise quantification of DNA orientation and conformation," USNC-URSI National Radio Science Meeting, January 2011

6.) P. S. Spuhler, L. Sola, M. R. Monroe, M. Chiari, and M. S. Ünlü, "Applications of potential dependent DNA orientation on indium tin oxide surface by fluorescent-self interference microscopy," BMES 2010 Annual Meeting, October 2010

5.) P. S. Spuhler, L. Sola, M. R. Monroe, M. Chiari, and M. S. Ünlü, "Measurement of potential dependent DNA orientation on indium tin oxide surfaces by fluorescent-self interference microscopy," 12th International Conference on Transparent Optical Networks, Munich, June 2010

4.) J. Knezevic, P. S. Spuhler, Q. Bao, P. Dröge, M. S. Ünlü, and U. Rant, "A platform for in situ real-time measurement of protein induced conformational changes of DNA," Biosensors, 2010, Glasgow, Scotland , May 2010

3.) P. S. Spuhler, J. Knezevic, A. Yalcin, Q. Bao, P. Dröge, U. Rant, and M. S. Ünlü, "Real-Time Kinetics Measurements of Protein Induced Conformational Changes in DNA," Proceedings of IEEE Photonics Society 2009 Annual Meeting, 7 October 2009

2.) P. S. Spuhler, J. Knezevic, A. Yalcin, Q. Bao, P. Dröge, U. Rant, and M. S. Ünlü, "A Platform for in situ Real-Time Measurement of Protein Induced Conformational Changes of DNA," Proceedings of IEEE Photonics Society 2009 Annual Meeting, 7 October 2009

1.) M. S. Ünlü, E. Ozkumur, J. Needham, D. A. Bergstein, B. B. Goldberg, A. Yalcin, P. S. Spuhler, R. Irani, and C. DeLisi, "Applications of Optical Resonance to Biological Imaging and Label-free Protein Microarrays (invited paper)," EMBC08, Vancouver, Canada, August 20-24, 2008, 2008

Theses

1.) P. S. Spuhler, "HIGH-THROUGHPUT DETECTION OF DNA ORIENTATION AND CONFORMATION FOR CHARACTERIZATION OF PROTEIN-DNA INTERACTIONS ," Ph.D. Dissertation, October 2011

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