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Optical Characterization and Nanophotonics Laboratory

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Biological Sensors

Members: Oguzhan Avci, Jyothsna Chinnala, Fulya Ekiz Kanik, Bennett B. Goldberg, Nese Lortlar Ünlü, Steven M Scherr, Anna K. Swan, M. Selim Ünlü, Negin Zaraee

 

Alumni: Ronen Adato, Sunmin Ahn, John Chandler Aldridge, Matthew Francis Anthes-Washburn, Adelaja A. Arojuraye, Prity Bengani, Eva Cornell, George Gaby Daaboul, Jack De Groot, Katrien De Vos, Tejal A Desai, Jonathan Zachary Egan, Jonathan Gershoni, Sylvain Gioux, Rodrigo Gonzalez, Rostem Irani, Vianney Jayasinha, Carlos A. Lopez, Herve Phillipe Mathelier, Elaine Mau, Margo R. Monroe, James Needham, Tugba Ozdemir, Alexander Reddington, Michael Patrick Shaw, Ahmet Tuysuzoglu, Gökhan Ulu, Yajie Wang, Ayca Yalcin, Angela Ying, Xirui Zhang

 

Publications

O. Avci, M. I. Campana, C. Yurdakul, and M. S. Ünlü, "Pupil function engineering for enhanced nanoparticle visibility in wide-field interferometric microscopy," Optica, Vol. 4, No. 2, 14 February 2017, pp. 247-254

J. T. Trueb, O. Avci, D. D. Sevenler, J. H. Connor, and M. S. Ünlü, "Robust Visualization and Discrimination of Nanoparticles by Interferometric Imaging," IEEE Journal of Selected Topics in Quantum Electronics, December 2016

D. D. Sevenler, and M. S. Ünlü, "Numerical techniques for high-throughput reflectance interference biosensing," Journal of Modern Optics, Vol. 63, No. 11, 16 June 2016, pp. 1115-1120

H. E. Fawcett, M. S. Ünlü, and J. H. Connor, "Viewpoint: New Approaches for Virus Detection through Multidisciplinary Partnerships," ACS Infectious Diseases, May 2016, pp. DOI: 10.1021/acsinfecdis.6b00063

S. M. Scherr, G. G. Daaboul, J. T. Trueb, D. D. Sevenler, H. E. Fawcett, B. B. Goldberg, J. H. Connor, and M. S. Ünlü, "Real-Time Capture and Visualization of Individual Viruses in Complex Media," Acs Nano, No. DOI: 10.1021/acsnano, January 2016

X. Zhang, G. G. Daaboul, P. S. Spuhler, P. Dröge, and M. S. Ünlü, "Quantitative characterization of conformational-specific protein–DNA binding using a dual-spectral interferometric imaging biosensor," Nanoscale, No. DOI: 10.1039/C5NR067, 2016

E. Cevik, G. G. Daaboul, X. Zhang, S. M. Scherr, N. Lortlar Ünlü, J. H. Connor, and M. S. Ünlü, "DNA-Directed Antibody Immobilization for Enhanced Detection of Single Viral Pathogens," Analytical Chemistry, Vol. 87, No. 20, October 2015, pp. 10505-10512, DOI:10.1021/acs.analchem.5b02702

O. Avci, N. Lortlar Ünlü, A. Yalcin, and M. S. Ünlü, "Interferometric Reflectance Imaging Sensor (IRIS)—A Platform Technology for Multiplexed Diagnostics and Digital Detection," Sensors, Vol. 15, No. 7, July 2015, pp. 17649-17665; doi:10.3390/s150717649

D. D. Sevenler, N. Lortlar Ünlü, and M. S. Ünlü, "Nanoparticle Biosensing With Interferometric Reflectance Imaging ," Nanobiosensors and Nanobioanalyses, Eds. Vestergaard, Kerman, Hsing, Tamiya, Springer, ISBN 978-4-431-55189-8. , February 2015

M. Cretich, G. G. Daaboul, L. Sola, M. S. Ünlü, and M. Chiari, "Digital detection of biomarkers assisted by nanoparticles: application to diagnostics," Trends in Biotechnology, 2015

M. S. Ünlü, "Digital Detection of Nanoparticles: Viral Diagnostics and Multiplexed Protein and Nucleic Acid Assays," Materials Research Society Proceedings Fall 2014, Vol. 1720, December 2014

C. Yu, C. A. Lopez, H. Hu, Y. Xia, D. S. Freedman, A. Reddington, G. G. Daaboul, M. S. Ünlü, and C. A. Genco, "A high-throughput method to examine protein-nucleotide interactions identifies targets of the bacterial transcriptional regulatory protein Fur.," PLoS ONE, Vol. 9, No. 5, May 2014

G. G. Daaboul, C. A. Lopez, J. Chinnala, B. B. Goldberg, J. H. Connor, and M. S. Ünlü, "Digital Sensing and Sizing of Vesicular Stomatitis Virus Pseudotypes in Complex Media: A Model for Ebola and Marburg Detection," Acs Nano, Vol. 8, No. 6, 19 May 2014, pp. 6047–6055

A. Reddington, "Instrument Design and Optimization of Interferometric Reflectance Imaging Sensors for In Vitro Diagnostics," Ph.D. Dissertation, January 2014

A. Reddington, J. T. Trueb, D. S. Freedman, A. Tuysuzoglu, G. G. Daaboul, C. A. Lopez, W. C. Karl, J. H. Connor, H. E. Fawcett, and M. S. Ünlü, "An Interferometric Reflectance Imaging Sensor for Point of Care Viral Diagnostics," IEEE Transactions on Biomedical Engineering, Vol. 60, No. 12, December 2013, pp. 3276-3283

A. Reddington, M. R. Monroe, and M. S. Ünlü, "Integrated Imaging Instrument for Self-Calibrated Fluorescence Protein Microarrays," Review of Scientific Instruments, Vol. 84, No. 10, 4 October 2013

S. Ahn, D. S. Freedman, X. Zhang, and M. S. Ünlü, "High-throughput label-free detection of DNA hybridization and mismatch discrimination using interferometric reflectance imaging sensor," Nucleic Acid Detection: Methods in Molecular Biology, Vol. 1039, September 2013

S. Ahn, D. D. Sevenler, and M. R. Monroe, "Biosensors - Innovations in nanobiosensing and biophotonics at Boston University," Boston University, August 2013

S. Ahn, D. S. Freedman, P. Massari, M. Cabodi, and M. S. Ünlü, "A Mass-Tagging Approach for Enhanced Sensitivity of Dynamic Cytokine Detection Using a Label-Free Biosensor," Langmuir, Vol. 29, No. 17, April 2013, pp. 5369-5376

M. R. Monroe, G. G. Daaboul, A. Tuysuzoglu, C. A. Lopez, F. F. Little, and M. S. Ünlü, "Single Nanoparticle Detection for Multiplexed Protein Diagnostics with Attomolar Sensitivity in Serum and Unprocessed Whole Blood," Analytical Chemistry, Vol. 85, No. 7, March/April 2013, pp. 3698-3706

M. Cretich, M. R. Monroe, A. Reddington, X. Zhang, G. G. Daaboul, F. Damin, L. Sola, M. S. Ünlü, and M. Chiari, "Interferometric silicon biochips for label and label-free DNA and protein microarrays.," Proteomics, Vol. 12, 2013, pp. 2963-2977

S. Ahn, C. Huang, E. Ozkumur, X. Zhang, J. Chinnala, A. Yalcin, S. Bandyopadhyay, S. Russek, M. S. Ünlü, C. DeLisi, and R. Irani, "TATA binding proteins can recognize nontraditional DNA sequences," Biophysical Journal, Vol. 103, October 2012, pp. 1510-1517

G. G. Daaboul, C. A. Lopez, A. Yurt, B. B. Goldberg, J. H. Connor, and M. S. Ünlü, "Optical Biosensors for Virus Detection and Characterization," IEEE Journal of Selected Topics in Quantum Electronics, Vol. 18, No. 4, July/August 2012, pp. 1422-1433

G. di Carlo, F. Damin, M. S. Ünlü, P. S. Spuhler, and M. Chiari, "Synthesis and conformational characterization of functional di-block copolymer brushes for microarray technology," Surface Science, Vol. 258, 1 February 2012, pp. 3750-3756

A. Yurt, G. G. Daaboul, J. H. Connor, B. B. Goldberg, and M. S. Ünlü, "Single nanoparticle detectors for biological applications," Nanoscale, Vol. 4, No. 3, 2012, pp. 715 - 726

P. S. Spuhler, "HIGH-THROUGHPUT DETECTION OF DNA ORIENTATION AND CONFORMATION FOR CHARACTERIZATION OF PROTEIN-DNA INTERACTIONS ," Ph.D. Dissertation, October 2011

P. S. Spuhler, L. Sola, X. Zhang, M. R. Monroe, J. T. Greenspun, M. Chiari, and M. S. Ünlü, "A Nano-Electromechanical Biosensor Based on Precise Quantification and Control of DNA Orientation," 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 3 September 2011

M. Cretich, A. Reddington, M. R. Monroe, M. Bagnati, F. Damin, L. Sola, M. S. Ünlü, and M. Chiari, "Silicon biochips for dual label-free and fluorescence detection: Application to protein microarray development.," Biosensors and Bioelectronics, Vol. 26, No. 9, 15 May 2011, pp. 3938-3943

G. G. Daaboul, R. S. Vedula, S. Ahn, C. A. Lopez, A. Reddington, E. Ozkumur, and M. S. Ünlü, "LED-based Interferometric Reflectance Imaging Sensor for quantitative dynamic monitoring of biomolecular interactions," Biosensors and Bioelectronics, Vol. 26, January 2011, pp. 2221-2227

M. S. Ünlü, P. S. Spuhler, L. Sola, M. R. Monroe, X. Zhang, and M. Chiari, "A platform for the precise quantification of DNA orientation and conformation," USNC-URSI National Radio Science Meeting, January 2011

G. G. Daaboul, P. F. Renda, R. R. Graef, A. Yurt, X. Zhang, C. A. Lopez, J. H. Connor, G. M. Hwang, B. B. Goldberg, and M. S. Ünlü, "IRIS:LED-interferometric reflectance imaging sensor for label-free detection of nanoparticles ," SPIE Photonics West 2011-BIOS, January 2011

G. G. Daaboul, P. F. Renda, R. R. Graef, A. Yurt, X. Zhang, C. A. Lopez, J. H. Connor, B. B. Goldberg, G. M. Hwang, and M. S. Ünlü, "IRIS: Interferometric Reflectance Imaging Sensor for Virus Detection(Invited) ," Materials Research Society Proceeding Fall 2010, November 2010

A. Yurt, G. G. Daaboul, X. Zhang, G. M. Hwang, B. B. Goldberg, and M. S. Ünlü, "Widefield Interferometric Detection and Size Determination of Dielectric Nanoparticles," Proceedings of IEEE Photonics Society 2010 Annual Meeting, 11 November 2010

G. G. Daaboul, A. Yurt, X. Zhang, G. M. Hwang, B. B. Goldberg, and M. S. Ünlü, "High-Throughput Detection and Sizing of Individual Low-Index Nanoparticles and Viruses for Pathogen Identification," Nano Letters, Vol. 11, October 2010, pp. 4727-4731

P. S. Spuhler, L. Sola, M. R. Monroe, M. Chiari, and M. S. Ünlü, "Applications of potential dependent DNA orientation on indium tin oxide surface by fluorescent-self interference microscopy," BMES 2010 Annual Meeting, October 2010

M. Cretich, D. Breda, F. Damin, M. Borghi, L. Sola, M. S. Ünlü, S. E. Burastero, and M. Chiari, "Allergen microarrays on high-sensitivity silicon slides," Analytical and Bioanalytical Chemistry, No. DOI 10.1007/s00216-0, 22 August 2010

A. Yurt, G. G. Daaboul, X. Zhang, B. B. Goldberg, and M. S. Ünlü, "Spectral Scattering Imaging for Single Particle Detection and Size Discrimination," Nano-TR, June 2010

G. G. Daaboul, C. A. Lopez, J. H. Connor, G. M. Hwang, O. Rabin, P. F. Renda, R. R. Graef, and M. S. Ünlü, "LED-based spectral reflectance imaging biosensor for label-free single pathogen detection," Biosensors, 2010, Glasgow, Scotland , May 2010

M. S. Ünlü, D. A. Bergstein, M. F. Ruane, and B. B. Goldberg, "Resonant cavity biosensor ," United States Patent Issued, No. 7,695,680, 13 April 2010

E. Ozkumur, S. Ahn, A. Yalcin, C. A. Lopez, E. Cevik, R. Irani, C. DeLisi, M. Chiari, and M. S. Ünlü, "Label-free microarray imaging for direct detection of DNA hybridization and single-nucleotide mismatches," Biosensors and Bioelectronics, Vol. 25, No. 7, 15 March 2010, pp. 1789-1795

R. Irani, E. Ozkumur, S. Ahn, A. Yalcin, M. S. Ünlü, and C. DeLisi, "Label-free, high-throughput DNA-protein interaction studies: Re-evaluating Eukaryotic Transcription.," Pittcon 2010, 4th March 2010

G. G. Daaboul, R. S. Vedula, A. Reddington, E. Ozkumur, C. A. Lopez, J. H. Connor, H. Fawcett, and M. S. Ünlü, "LED-based spectral reflectance imaging biosensor for label-free high-throughput multi-analyte and single-pathogen detection ," SPIE Photonics West 2010 - BIOS, January/February 2010

E. Ozkumur, A. Yalcin, M. Cretich, M. S. Ünlü, and M. Chiari, "Label-free, dynamic and quantitative measurement of biomolecular interactions," 23rd International Symposium on MicroScale Bioseparations (MSB) 2009, February 2009

J. R. Dupuis, and M. S. Ünlü, "Time-Domain Surface Profile Imaging via HS-FTS," Optics Letters, Vol. 33, June 2008, pp. 1368-1370

M. S. Ünlü, and B. B. Goldberg, "Applications of Optical Resonance to Biological Sensing and Imaging (invited)," OSA Frontiers in Optics 2006/Laser Science XXII, Rochester, New York, October 8-12, 2006., 8-12 October 2006

A. Yalcin, K. C. Popat, J. C. Aldridge, T. A. Desai, J. Hryniewicz, N. Chbouki, B. E. Little, O. King, V. Van, S. T. Chu, D. Gill, M. F. Anthes-Washburn, M. S. Ünlü, and B. B. Goldberg, "Optical Sensing of Biomolecules Using Microring Resonators," IEEE Journal of Selected Topics in Quantum Electronics, Vol. 12, January/February 2006, pp. 148-155

M. S. Ünlü, and B. B. Goldberg, "Applications of Optical Resonance to Biological Sensing and Imaging (invited)," OSA Frontiers in Optics 2006/Laser Science XXII, Rochester, New York, October 8-12, 2006., 2006

M. S. Ünlü, "Applications of microresonators: from photodetectors to biological sensing and imaging (Keynote Presentation)," European Optical Society Topical Meeting: Optical Microsystems, 15 September 2005

A. Yalcin, K. C. Popat, M. F. Anthes-Washburn, N. Chbouki, T. A. Desai, M. S. Ünlü, and B. B. Goldberg, "Microring resonators for biochemical sensing," Proceedings of CLEO/QELS 2005, May 2005

A. Yalcin, "Label-Free Optical Sensing Of Biomolecules Using Microring Resonators," Master Thesis, May 2005

A. Yalcin, J. C. Aldridge, K. C. Popat, T. A. Desai, N. Chbouki, M. S. Ünlü, and B. B. Goldberg, "Microring resonators for biochemical sensing," Bulletin of APS Meeting, March 2005


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